Association of MRI leptomeningeal enhancement with disability worsening in progressive multiple sclerosis: A clinical and post-mortem study.

Marco Vercellino,Gianfranco Costantini,Maurizio Cogoni, Laura Lequio, Paola Sciortino, Federica De Negri,Stella Marasciulo, Consuelo Valentini,Chiara Bosa,Paola Garelli, Anna Rolando,Andrea Calvo, Giovanni Morana,Paola Cavalla

Multiple sclerosis (Houndmills, Basingstoke, England)（2023）

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摘要

LME is frequently detected in pMS patients using 1.5T MRI and is independently predictive of disability progression. LME could result from both focal leptomeningeal post-inflammatory fibrosis and inflammation.

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关键词

Progressive multiple sclerosis, disability, leptomeningeal enhancement, meningeal inflammation, meningeal fibrosis, brain volume

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