A novel MRI-based volumetric index for monitoring the motor symptoms in Parkinson's disease

Anupa A. Vijayakumari, Nymisha Mandava,Olivia Hogue,Hubert H. Fernandez,Benjamin L. Walter

Journal of the neurological sciences（2023）

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摘要

•An early biomarker to track motor symptom progression in PD is still lacking.•A novel volumetric index was developed using baseline MRI scans.•PD patients with higher index values exhibited faster motor symptom progression.

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关键词

Magnetic resonance imaging,Parkinson's disease,Mahalanobis distance,Imaging biomarker,Motor symptom progression,Linear mixed-effects models

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