The immune checkpoint adenosine 2A receptor is associated with aggressive clinical outcomes and reflects an immunosuppressive tumor microenvironment in human breast cancer.

Basma Zohair,Dounia Chraa, Ibtissam Rezouki,Hamza Benthami,Ibtissam Razzouki,Mohamed Elkarroumi,Daniel Olive,Mehdi Karkouri,Abdallah Badou

Frontiers in immunology（2023）

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摘要

The present study is the first to elucidate the clinical and immunological relevance of A2AR in breast cancer patients. In light of these findings, A2AR could be deemed a promising therapeutic target to overcome immune evasion prevailing within the TME of breast cancer patients.

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human breast cancer,immunosuppressive tumor microenvironment,breast cancer,tumor microenvironment

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