A Novel Dual-Function Redox Modulator Relieves Oxidative Stress and Anti-Angiogenic Response in Placental Villus Explant Exposed to Hypoxia-Relevance for Preeclampsia Therapy.

Diana Pintye,Réka E Sziva,Maxim Mastyugin,Brett C Young,Sonako Jacas,Marianna Török,Saira Salahuddin,Prakash Jagtap,Garry J Southan,Zsuzsanna K Zsengellér

Biology（2023）

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摘要

The redox modulator AKT-1005 has the potential to intervene with oxidative stress and can be efficacious for PE therapy. Future studies are underway to assess the in vivo efficacy of HMP.

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关键词

preeclampsia, nitric oxide-donor, redox modulator, SOD mimetic, placental villous explant, hypoxia

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