The Impact of Drug-Drug Interactions on the Toxicity Profile of Combined Treatment with BRAF and MEK Inhibitors in Patients with BRAF-Mutated Metastatic Melanoma.

Silvia Mezi,Andrea Botticelli,Simone Scagnoli,Giulia Pomati,Giulia Fiscon,Federica De Galitiis,Francesca Romana Di Pietro,Sofia Verkhovskaia,Sasan Amirhassankhani,Simona Pisegna,Giovanna Gentile,Maurizio Simmaco, Bjoern Gohlke,Robert Preissner,Paolo Marchetti

Cancers（2023）

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摘要

DDIs emerged as a critical issue for the risk of treatment-related cardiovascular toxicity. Our findings support the utility of DDI assessment in melanoma patients treated with BRAF/MEK inhibitors.

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关键词

BRAF inhibitors, MEK inhibitors, BRAF mutation, metastatic melanoma, drug-drug interaction, cardiological toxicity

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