eNOS Regulates Lymphatic Valve Specification by Controlling β-Catenin Signaling During Embryogenesis in Mice.

Drishya Iyer,Diandra M Mastrogiacomo,Kunyu Li,Richa Banerjee,Ying Yang,Joshua P Scallan

Arteriosclerosis, thrombosis, and vascular biology（2023）

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摘要

In conclusion, we demonstrate a novel, NO-independent role for eNOS in regulating lymphatic valve specification and propose a mechanism by which eNOS directly binds β-catenin to regulate its nuclear translocation and thereby transcriptional activity.

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关键词

cadherins,catenins,lymphedema,mechanotransduction, cellular,mice

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