Effect of Mandibular Advancement Splint Therapy on Cardiac Autonomic Function in Obstructive Sleep Apnoea

Purpose This study aimed to evaluate the effect of mandibular advancement splint (MAS) therapy on cardiac autonomic function in patients with obstructive sleep apnoea (OSA) using heart rate variability (HRV) analysis. Methods Electrocardiograms (ECG) derived from polysomnograms (PSG) of three prospective studies were used to study HRV of patients with OSA before and after MAS treatment. HRV parameters were averaged across the entire ECG signal during N2 sleep using 2-min epochs shifted by 30 s. Paired t-tests were used to compare PSG and HRV measures before and after treatment, and the percent change in HRV measures was regressed on the percent change in apnoea-hypopnea index (AHI). Results In 101 patients with OSA, 72% were Caucasian, 54% men, the mean age was 56 11 years, BMI 29.8 +/- 5.3 kg/m(2), and treatment duration was 4.0 +/- 3.2 months. After MAS therapy, there was a significant reduction in OSA severity (AHI,-18 +/- 16 events per hour, p<0.001) and trends towards increased low-frequency to high-frequency ratio, low-frequency power, and reduced high-frequency power (LF:HF,-0.4 +/- 1.5, p=0.01; LF,-3 +/- 16 nu, p=0.02, HF, 3.5 +/- 13.7 nu, p=0.01). Change in NN intervals correlated with the change in AHI (beta(SE)=-2.21 (0.01), t=-2.85, p=0.005). No significant changes were observed in the time-domain HRV markers with MAS treatment. Conclusion The study findings suggest that successful MAS treatment correlates with changes in HRV, specifically the lengthening of NN intervals, a marker for improved cardiac autonomic adaptability.