Diagnosis of invasive pulmonary aspergillosis by lateral flow assay of galactomannan in bronchoalveolar lavage fluid: a meta-analysis of diagnostic performance.
Letters in applied microbiology(2023)
摘要
The performance of lateral flow assay (LFA) in diagnosing invasive pulmonary aspergillosis (IPA) has not been well demonstrated. To address this, we conducted a meta-analysis assessing the overall accuracy of LFA in diagnosing IPA using bronchoalveolar lavage fluid. Over a systematical search and assessment of bias risk, we calculated the pooled specificity, sensitivity, and area under the receiver operating curve (AUC) to assess the diagnostic performance. Our meta-analysis included 11 studies. The combined total sensitivity and specificity for diagnosing IPA was 0.78 (95%CI: 0.71, 0.83) and 0.87 (95%CI: 0.81, 0.91), respectively. The AUC was 0.86 (95%CI: 0.82, 0.89). Our results demonstrate that LFA using Galactomannan in BALF exhibits high sensitivity and specificity for diagnosing IPA.
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关键词
invasive pulmonary aspergillosis, galactomannan, bronchoalveolar lavage fluid, meta-analysis, lateral flow assay
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