XB130 inhibits healing of diabetic skin ulcers through the PI3K/Akt signalling pathway.

Xin-Lin Zhu,Dong-Ying Hu,Zhao-Xiang Zeng,Wei-Wei Jiang,Tian-Yang Chen,Tian-Cheng Chen,Wan-Qing Liao,Wen-Zhi Lei,Wen-Jie Fang,Wei-Hua Pan

World journal of diabetes（2023）

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摘要

The findings of this study indicated that the expression of XB130 is up-regulated in high glucose-stimulated diabetic skin ulcers and HUVECs. Knockdown of XB130 promotes cell proliferation and angiogenesis the PI3K/Akt signalling pathway, which accelerates the healing of diabetic skin ulcers.

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关键词

XB130, Diabetes mellitus, Diabetic skin ulcers, PI3K/Akt signalling pathway

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