Factors Associated with Radiation Necrosis and Intracranial Control in Patients Treated with Immune Checkpoint Inhibitors and Stereotactic Radiotherapy.

PD-L1 expression (≥50%) may be associated with higher rates of G2+ radiation necrosis, and there may be improved intracranial control following the development of radiation necrosis. Administration of ICIs with SRS/SRT is overall safe, and there may be some local control benefit to delivering these concurrently.