Sulfonated polystyrenes: pH and Mg2+-insensitive amphiphilic copolymers for detergent-free membrane protein isolation

Miroslav Janata, Sachin Gupta,Eva Čadová,Pavla Angelisová,Bankala Krishnarjuna,Ayyalusamy Ramamoorthy,Václav Hořejší,Vladimír Raus

EUROPEAN POLYMER JOURNAL（2023）

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摘要

•A library of sulfonated polystyrenes differing in MW and polarity was synthesized.•Polymers effective in solubilizing model cell membranes were identified.•The lead polymer forms stable particles (nanodiscs) from model DMPC liposomes.•Polymers remain soluble at low pH and in the presence of Mg2+ ions.

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关键词

Amphiphilic copolymer,Sulfonated polystyrene,Membrane protein,Solubilization,Cell membrane

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