Single-cell analysis of graft-infiltrating host cells identifies caspase-1 as a potential therapeutic target for heart transplant rejection.

Zhichao Wu,Jialiang Liang,Shuoji Zhu,Nanbo Liu,Mingyi Zhao, Fei Xiao,Guanhua Li,Changjiang Yu,Chengyu Jin,Jinshan Ma,Tucheng Sun,Ping Zhu

Frontiers in immunology（2023）

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摘要

The single-cell transcriptional profile highlighted the crucial role of caspase-1 in interferon-mediated inflammatory monocytes infiltrating heart transplants, suggesting its potential as a therapeutic target for attenuating rejection.

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关键词

host cells,potential therapeutic target,single-cell,graft-infiltrating

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