Intercellular Mechanisms of Therapeutic Resistance at the Tumor-Stromal Interface Using Ultra High-Plex Single-Cell Spatial Transcriptomics and Genetically-Engineered Tumoroids

C. Shiau, J. Cao, M. Gregory, Y. Kim, S. He, J. Reeves,S. Wang, N. A. Lester, J. Su,P. L. Wang,J. Beechem,T. S. Hong,J. Y. Wo, D. Ting,M. Hemberg, W. L. Hwang

International journal of radiation oncology, biology, physics（2023）

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摘要

In this study, we integrated ultra high-plex single-cell spatial transcriptomics, optimal transport ligand-receptor predictions, and genetically-engineered stromal tumoroids to identify and validate CLCF1-CNTFR as an important intercellular mechanism of resistance to chemoradiotherapy in PDAC-pioneering a paradigm for translating single-cell spatial biology to clinical oncology.

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关键词

intercellular mechanisms,therapeutic resistance,tumor-stromal,high-plex,single-cell,genetically-engineered

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