Prognostic Impact of Mismatch Repair Deficiency on Stage I-II Endometrioid Endometrial Cancer Treated with Adjuvant Radiation Therapy: A Multi-Institutional Analysis

Z. Sherwani, J. Alegun,A.L. Russo, S. Damast,K.V. Albuquerque, C.R. Nwachukwu, M.A. Dyer, E.C. Fields, S. Beriwal,Z.D. Horne,I. Vergalasova,N. Ohri,N.K. Taunk, J.P. Chino,E.A. Kidd,E.W. Leung, J. Song, L. Hathout

International journal of radiation oncology, biology, physics（2023）

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摘要

Preliminary data from 7 out of 11 participating institutions showed that dMMR status leads to significantly decreased RFS in patients with early-stage EEC. While awaiting the results of NRG GYN020 and RAINBO prospective trials, this large study suggests that treatment intensification could be warranted in patients with dMMR early-stage EEC.

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关键词

mismatch repair deficiency,adjuvant radiation therapy,radiation therapy,multi-institutional

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