Hypoxia-Inducible Transgelin-2 Confers Treatment Resistance through Activation of PI3K/Akt/GSK3 Pathway in Glioblastoma

A. Kumar, P. Rajasekera, V. Becker, S. Biehn, B. Perez-Soto,S. Beyer,J. McElroy,A. Becker,B. Johnson,T. Cui, E. Sebastian, A. Grosu, S. Lindert, E. H. Bell, H. Manring, J. Haque, A. Chakravarti

International journal of radiation oncology, biology, physics（2023）

引用 0|浏览1

暂无评分

摘要

Our in vitro and in vivo xenograft studies suggest that TAGLN2 confers treatment resistance to GBM contributing to tumor recurrence. Altogether, TAGLN2 may serve as a potential therapeutically vulnerable target in GBM specifically through its role in cell survival and invasion.

查看译文

关键词

pi3k/akt/gsk3β pathway,hypoxia-inducible

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要