Dynamic Changes of Molecular Subtype Classification and Genomic Classifier Scores in High-Risk Prostate Cancer Patients Undergoing Pre-Operative Stereotactic Body Radiation Therapy

M. Diven, A. Hakansson,Y. Liu,E. Davicioni, A. Dillard,F. Khani, S. Wolfe,J. C. Hu, D. S. Scherr,T. D. McClure, C. E. Barbieri, H. Nagar,A. E. Marciscano

International journal of radiation oncology, biology, physics（2023）

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摘要

A majority of subjects demonstrate a post-SBRT increase in GC score with reclassification of genomic-prognostic risk group in 58%. An enrichment of the basal-immune molecular subtype was observed following SBRT suggesting a convergence towards this biology in irradiated tumors.

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关键词

molecular subtype classification,prostate cancer,genomic classifier scores,high-risk,pre-operative

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