RGS2 is an innate immune checkpoint for TLR4 and Gαq-mediated IFNγ generation and lung injury.

bioRxiv : the preprint server for biology(2023)

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摘要
Authors demonstrate an essential role of RGS2 in macrophages in airspace to promoting anti-inflammatory function of alveolar macrophages in lung injury. The authors provided new insight into the dynamic control of innate immune response by Gαq and RGS2 axis to prevent ALI.
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