Design of Target Response Wettability Switchable Core-Shell-shell Electrochemiluminescence Nanoprobes for Sensitive Hyaluronidase Detection.

Electrochemiluminescence nanoprobes with a core-shell-shell structure have been designed and applied for hyaluronidase detection. The nanoprobes can precipitate efficiently through target-regulation wettability for collection, and enrich near to the hydrophobic electrode surface through hydrophobic interaction to enhance the performance of the biosensor. The electrochemiluminescence nanoprobes can precipitate efficiently through target-regulation wettability for collection, and enrich near to the hydrophobic electrode surface through hydrophobic interaction to enhance the biosensor's performance.