Expression of Tim-3/galectin-9 pathway and CD8+T cells and related factors in patients with cystic echinococcosis.

Hui Zhao,Yuyu Ma,Fengming Tian,Bin Li,Ning Xiao,Xiaojin Mo,Madinaimu Aibibula,Hongyue Min,Xuanlin Cai,Ting Zhang,Xiumin Ma

Experimental parasitology（2023）

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摘要

This study suggests that the high expression of Tim-3 on CD8+T cell surfaces in AE patients might promote an increase in CD8CD28-T cells and related factors, while suppressing CTL and related factor expressions. This potentially induces the onset of immune tolerance, which is unfavorable for the clearance of Echinococcus multilocularis in patients, leading to the exacerbation of persistent infections.

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关键词

Cystic echinococcosis, Tim-3/Galectin-9 pathway, CD8+T cells, CTL, CD8+CD28-T cells

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