Correction: Hormonal treatment for newly diagnosed metastatic prostate cancer: a population-based study from the California cancer registry

Prostate Cancer and Prostatic Diseases(2023)

引用 0|浏览0
暂无评分
摘要
Introduction To evaluate how often men with metastatic prostate cancer (mPC) receive standard of care treatment with androgen deprivation therapy (ADT). Methods Men aged ≥20 years with newly diagnosed mPC (stage IV) between 2010 and 2018 were identified using California Cancer Registry data. Receipt of hormonal therapy as initial cancer treatment was examined by patient/tumor characteristics at time of diagnosis. Chi-square tests and logistic regression, adjusted for covariates, were performed to assess association between receipt of hormonal therapy and patient/tumor characteristics. Results We identified 13,680 men with newly diagnosed mPC, of which 3637 had local metastasis (N1) only while 9596 had distant metastasis (M1) with or without N1 disease. 21.8 % ( n = 2980) of men did not receive ADT. The highest rate of receiving ADT was among men between ages 75–84 (81.6%) and the lowest rate was in men over 85 (76.0%). Asian men had the largest proportion receiving ADT ( n = 962, 81.5%) with remaining subgroups having similar proportion of men receiving ADT (76.8% to 77.2%). Once adjusted for covariates, regression results showed men with a higher Gleason score (8–10) were more likely to receive ADT (OR 2.04, 1.82–2.27, p = < 0.001) as well as men with distant sites of metastatic disease (OR 4.02, 3.62–4.46, p = < 0.001). Men residing in neighborhoods with the lowest socioeconomic status were least likely to receive ADT (OR 0.79, 0.68–0.93, p = 0.0032). No differences in receipt of ADT were observed by race/ethnicity. Discussion Despite significant advancements in the treatment of mPC in recent years, over one-fifth of patients did not receive ADT, which is the backbone for all new systemic therapies. This dataset might help address some of the prostate cancer care disparities in California.
更多
查看译文
关键词
metastatic prostate cancer,prostate cancer,hormonal treatment,population-based
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要