BAllC and BAllCools: Efficient Formatting and Operating for Single-Cell DNA Methylation Data

biorxiv(2024)

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摘要
Motivation With single-cell DNA methylation studies yielding vast datasets, existing data formats struggle with the unique challenges of storage and efficient operations, highlighting a need for improved solutions. Results BAllC (Binary All Cytosines) emerges as a tailored binary format for methylation data, addressing these challenges. BAllCools, its complementary software toolkit, enhances parsing, indexing, and querying capabilities, promising superior operational speeds and reduced storage needs. Availability Contact ecker{at}salk.edu Supplementary information Supplementary data are available at Bioinformatics online. ### Competing Interest Statement J.R.E is a member of the scientific advisor for Zymo Research In. and Ionis Pharmaceuticals.
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