GRAIL gene knockout mice protect against aging-related and noise-induced hearing loss.

Kai-Fen Chuang,Chih-Hung Wang,Hang-Kang Chen,Yuan-Yung Lin, Chia-Hsin Lin,Yi-Chun Lin,Cheng-Ping Shih,Chao-Yin Kuo,Ying-Chuan Chen,Hsin-Chien Chen

Journal of the Chinese Medical Association : JCMA（2023）

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摘要

The present data demonstrated that GRAIL deficiency protects against aging-related and noise-induced hearing loss. The mechanism involved needs to be further clarified from the potential association with synaptic modulation, inflammation, and oxidative stress.

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