HPV-positive clinically advanced squamous cell carcinoma of the urinary bladder (aBSCC): A comprehensive genomic profiling (CGP) study.

G H Ghelani,M Bou Zerdan,J Jacob,P E Spiess, R Li,A Necchi,P Grivas,A Kamat,N Danziger,D Lin,R Huang,B Decker,E S Sokol,L Cheng,D Pavlick, J S Ross,G Bratslavsky,A Basnet

Urologic oncology（2023）

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摘要

HPV+ aBSCC tends to occur more often in younger patients. As reported in other HPV-associated squamous cell carcinomas, HPV+ aBSCC demonstrates significantly reduced frequencies of inactivating mutations in cell cycle regulatory genes with similar GA in MTOR and PIK3CA pathways. The implication of HPV in the pathogenesis of bladder cancer remains unknown but warrants further exploration and clinical validation.

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关键词

Advanced Bladder Squamous Cell Cancer,CDKN2A/B mutation,Genomic Alteration,Human Papilloma Virus,Inactivating alterations,PD-L1, MTAP loss,TERT promoter mutation,TP53 mutation

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