Current Status of Catabolic, Anabolic and Inflammatory Biomarkers Associated with Structural and Symptomatic Changes in the Chronic Phase of Post-Traumatic Knee Osteoarthritis– a Systematic Review

Post-traumatic OA (PTOA) can occur within 5 years after a significant injury and is a valuable paradigm for identifying biomarkers. This systematic review aims to summarise published literature in human studies on the associations of known serum and synovial fluid biomarkers at least a year from injury to structural, symptomatic changes and underlying PTOA processes.