Ultrasound-Assisted Synthesis of Some Novel 1,3-Diarylpyrazolyl Α-Aminophosphonates Conjugated with Nitrogen Heterocycles As Antifungal Agents Using CdI 2 Nanoparticles As an Efficient Catalyst

Some novel 1,3-diarylpyrazolyl α-aminophosphonates conjugated with nitrogen heterocycles were synthesized via one-pot three-component reaction of 1,3-diaryl-1 H -pyrazole-4-carbaldehydes, N -amino hetero­cycles, and diethyl phosphonate in the presence of CdI 2 nanoparticles as an efficient catalyst under conventional heating at 80°C or ultrasonic (US) irradiation at 50°C. The latter protocol has essential advantages such as operational simplicity and excellent yields. The antifungal properties of the synthesized compounds were evaluated. Most of them showed excellent inhibitory activity against plant pathogenic fungi in comparison to propiconazole as reference fungicide.