The interaction of chlorin photosensitizers for photodynamic therapy with blood transport proteins

Philipp K. Morshnev,Andrey V. Kustov, Eduard A. Drondel, Ivan I. Khlydeev,Olga B. Abramova, Elena B. Yaroslavtseva-Isaeva,Elena V. Lyalyakina,Mikhail O. Koifman,Dmitry B. Berezin

Journal of Molecular Liquids（2023）

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摘要

•The interaction between a series of charged chlorins and serum transport proteins was studied.•The effect of the charge sign, number and position of charged groups were investigated.•The influence of synthetic carriers on photosensitizer transport by proteins was analysed.

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关键词

Photodynamic therapy, Photosensitizers, Blood transport proteins, Surfactants, Chlorin e 6, Gel filtration chromatography

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