First-Line Antituberculosis Drug Concentrations in Infants With HIV and a History of Recent Admission With Severe Pneumonia
JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY(2023)
摘要
Optimal antituberculosis therapy is essential for favorable clinical outcomes. Peak plasma concentrations of first-line antituberculosis drugs in infants with living HIV receiving WHO-recommended dosing were low compared with reference values for adults, supporting studies on increased doses of first-line TB drugs in infants. First-line antituberculosis drug peak concentrations in infants with HIV were low compared with reference values for adults. The percent peak concentrations within adult reference values were 51%, 22%, 76%, and 6% for isoniazid, rifampicin, pyrazinamide, and ethambutol, respectively.
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关键词
HRZE,Tuberculosis,HIV,pharmacokinetics,infants
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