Combining pharmacokinetic and electrophysiological models for early prediction of drug-induced arrhythmogenicity

Jordi Llopis-Lorente, Samuel Baroudi, Kévin Koloskoff,Maria Teresa Mora, Matthieu Basset,Lucía Romero, Sylvain Benito, Frederic Dayan,Javier Saiz,Beatriz Trenor

Computer methods and programs in biomedicine（2023）

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摘要

•Novel PK/EP methodology enhances TdP-risk in diverse patient sub-populations.•Sex and renal function impact drug-induced TdP risk.•Women with impaired renal function show heightened susceptibility to TdP.•The proposed methodology can help determine maximum dose regimens.

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关键词

Pharmacokinetic modeling,Torsade de Pointes,Cardiac safety,Population of models,Sex-specific cardiotoxicity

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