Endotype Characterization Reveals Mechanistic Differences Across Brain Regions in Sporadic Alzheimer's Disease.

Ashay O Patel,Andrew B Caldwell,Srinivasan Ramachandran,Shankar Subramaniam

Journal of Alzheimer's disease reports（2023）

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摘要

Our findings suggest that SAD manifestation varies in scale and severity in different brain regions. We identify endotypes, such as energetic shortfalls, impaired neuronal function, and dedifferentiation.

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关键词

Alzheimer's disease, dedifferentiation, endotype, energetics, NRF1, REST, SOX2, sporadic Alzheimer's disease, SUZ12, transcriptome

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