Complement-activating donor-specific anti-HLA antibodies in solid organ transplantation: systematic review, meta-analysis, and critical appraisal.

Solaf Al-Awadhi,Marc Raynaud,Kevin Louis,Antoine Bouquegneau,Jean-Luc Taupin,Olivier Aubert,Alexandre Loupy,Carmen Lefaucheur

Frontiers in immunology（2023）

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摘要

We demonstrated in this systematic review, meta-analysis and critical appraisal the significant deleterious impact and the independent prognostic value of circulating complement-activating anti-HLA DSAs on solid organ transplant risk of allograft loss and rejection.

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complement-activation, donor specific antibodies, anti-HLA, rejection, transplantation outcomes

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