The effect of Toll-like receptor agonists on the immunogenicity of MVA-SARS-2-S vaccine after intranasal administration in mice.

Kim Thi Hoang Do,Stefanie Willenzon,Jasmin Ristenpart,Anika Janssen,Asisa Volz,Gerd Sutter,Reinhold Förster,Berislav Bošnjak

Frontiers in cellular and infection microbiology（2023）

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摘要

Our study indicates a potential role of TLR-agonists as a tool to modulate immune responses to live vector vaccines. Particularly TLR3 agonists hold a promise to potentiate MVA-induced cellular immune responses. On the other hand, additional research is necessary to identify optimal combinations of agonists that could enhance MVA-induced humoral responses.

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关键词

modified vaccinia virus Ankara (MVA), respiratory tract, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Toll-like receptor (TLR) agonist, vaccination

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