Pharmacokinetics and pharmacodynamics of intranasal and intramuscular administration of naloxone in working dogs administered fentanyl.

Ciara A Barr,Joanne Haughan,Giacomo Gianotti,Kelley Varner,Kenneth J Drobatz,Darko Stefanovski,Mary Robinson,Mark Pennington,Amanda McGuire,Cynthia M Otto

Journal of veterinary internal medicine（2023）

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摘要

Although IM administration resulted in higher naloxone plasma concentrations compared to IN, reversal of sedation was achieved via both routes after administration of therapeutic doses of fentanyl.

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关键词

opioid,overdose,reversal,sedation

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