Fibroblast growth factor inhibition by molecular-targeted agents mitigates immunosuppressive tissue microenvironment in hepatocellular carcinoma.

Hiroyuki Suzuki,Hideki Iwamoto,Toshimitsu Tanaka,Takahiko Sakaue,Yasuko Imamura,Atsutaka Masuda,Toru Nakamura,Hironori Koga,Yujin Hoshida,Takumi Kawaguchi

Hepatology international（2023）

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摘要

In this study, we showed that cabozantinib activated the innate immune system, and lenvatinib and AZD4547, which commonly inhibit FGFR signaling, altered TIME to a hot immune state by downregulating lipid metabolism-related genes. These findings support the therapeutic use of combination immunotherapies.

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