Wnt/β-catenin and NFκB signaling synergize to trigger growth-factor-free regeneration of adult primary human hepatocytes.

Nuria Oliva-Vilarnau,Christian M Beusch,Pierre Sabatier,Eirini Sakaraki,Amelie Tjaden,Lukas Graetz,Florian A Büttner,Debra Dorotea,My Nguyen,Filip Bergqvist,Yvonne Sundström,Susanne Müller,Roman A Zubarev,Gunnar Schulte,Claudia Tredup,Roberto Gramignoli,Uwe J F Tietge,Volker M Lauschke

Hepatology (Baltimore, Md.)（2023）

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摘要

This study revealed a network of NFκB, TGFβ, and Wnt/β-catenin that controls human hepatocyte regeneration in the absence of exogenous growth factors, identified novel regulators of hepatocyte proliferation, and highlighted the potential of organotypic culture systems for chemogenomic interrogation of complex physiological processes.

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