Uncovering the Potential of CD40 Agonism to Enhance Immune Checkpoint Blockade.
Clinical cancer research : an official journal of the American Association for Cancer Research（2024）
摘要
In this CCR Translations, we discuss the therapeutic potential of CD40 agonism, which stimulates antigen-presenting cells (APC) to activate effector T and NK cells. CD40 agonism may lead to development of an interferon-activated, T cell-inflamed tumor microenvironment and has the potential to facilitate long-term response with immune checkpoint blockade. See related article by Weiss et al., p. 74.
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