Methylphenidate alleviates cognitive dysfunction from early Mn exposure: Role of catecholaminergic receptors.

Developmental Mn exposure impaired attention and sensorimotor functionMPH ameliorated the Mn deficits, but the effective dose varied by functional domainThe MPH benefit on attention was only apparent after prolonged treatmentNo specific catecholaminergic receptor singly mediates Mn-induced inattention or MPH efficacy in this domainDopamine 1 and 2 receptors moderated Mn sensorimotor deficits and MPH efficacy in this domainMPH can improve behavioral dysfunction induced by an environmental toxicant.