Dysregulated Immunity to Clostridioides difficile in IBD Patients Without a History of Recognized Infection.

Laura Cook,May Q Wong,William D Rees,Alana Schick,Daniel J Lisko, Genelle R Lunken, Xiaojiao Wang,Hannah Peters,Laura Oliveira,Torey Lau, Regan Mah,Brian Bressler,Megan K Levings,Theodore S Steiner

Inflammatory bowel diseases（2023）

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摘要

These data suggest that IBD patients, potentially due to underlying intestinal dysbiosis, experience undiagnosed C. difficile infections that result in impaired toxin-specific immunity. This may contribute to the development of inflammatory T cell responses toward commensal bacteria and provide a rationale for C. difficile testing in IBD patients.

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