Exercise sensitizes PD-1/PD-L1 immunotherapy as a hypoxia modulator in the tumor microenvironment of melanoma.

Huiyu Yan,Aimin Jiang,Yinong Huang,Jun Zhang,Wenguang Yang,Wei Zhang,Tianya Liu

Frontiers in immunology（2023）

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摘要

Exercise has the potential to function as a hypoxia modulator improving the tumor immune microenvironment, resulting in the promotion of anti-tumor efficacy and the facilitation of biologically safe sensitization of PD-1/PD-L1 immunotherapy.

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关键词

tumor microenvironment, exercise, hypoxia, PD-1/PD-L1 immunotherapy, immunotherapy sensitization

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