Ceftazidime/Avibactam Resistance in Carbapenemase-Producing Klebsiella pneumoniae

Qiaozhen Cui,Chen Wang,Qichen Wang,Juanxiu Qin,Min Li,Baixing Ding,Zhen Shen

Emerging infectious diseases（2023）

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摘要

We identified a novel ceftazidime/avibactam resistance mechanism in sequence type 11 Klebsiella pneumoniae carbapenemase 2-producing K. pneumoniae. Plasmid recombination and chromosomal integration formed a novel virulence plasmid and provided an additional promoter for blaSHV-12, leading to blaSHV-12 overexpression and ment contributed to convergence of hypervirulence and ceftazidime/avibactam resistance.

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关键词

<i>klebsiella pneumoniae</i>,ceftazidime/avibactam resistance,carbapenemase-producing

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