ATP-responsive and functionalized framework nucleic acid for synergistic radio-immunotherapy

Yuxin Zhang,Yuxi Zhan,Chenchen Mao,Guo Li,Yuxuan Zhao,Ye Chen,Yunfeng Lin

Chemical Engineering Journal（2023）

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摘要

•The first targeted platform of framework nucleic acid for radiotherapy is presented.•This delivery platform is ATP-targeted and can assist in low-dose radiotherapy.•The anti-tumor immune response is enhanced by promoting the maturation of DCs.

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关键词

Tetrahedral framework nucleic acid structure, Immunoadjuvant-functionalized nanostructure, ATP-responsive nanostructure, Radio-immunotherapy

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