The Current Mismatch Between COVID-19 Clinical Trial Design and the Evolving Profile of Hospitalized Patients: A Retrospective Cohort Analysis.

Rocio Montejano, Alfredo Soler-Carracedo,Alberto M Borobia,Alejandro Martin-Quiros, David Grandioso, Carlos Cañada, Alicia Roman,Jose R Arribas

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America（2024）

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摘要

Evaluating 100 adult coronavirus disease 2019 (COVID-19) patients at a Madrid hospital, we identified a mismatch between current clinical trial designs and the evolving profile of hospitalized patients. Most patients were ineligible due to design constraints, suggesting a need to rethink trial criteria for a more accurate representation of the hospitalized COVID-19 cohort.

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