Epilepsy surgery in children with genetic etiologies: A prospective evaluation of current practices and outcomes

•Surgery was effective in a majority of children with epilepsy from a genetic cause.•Surgery improved seizure frequency despite diffuse or multifocal MRI or EEG findings.•Seizure freedom was achieved in ⅓ of this cohort; median follow-up 11 months.•>50 % seizure reduction was present in ⅔ of children; median follow-up of 11 months.•There is a long latency between recognizing drug resistance and referral for surgery.