Convergent synthesis of proteins using peptide-aminothiazoline.
Chemical communications (Cambridge, England)(2023)
摘要
Sequential peptide coupling plays a central role in chemical protein synthesis. This paper describes a new peptide derivative, peptide-aminothiazoline (At), whereof the C-terminus is functionalized with 2-aminothiazoline. Peptide-At streamlined the sequential peptide ligation in a one-pot manner and demonstrated the convergent synthesis of a circular protein and homogeneous glycoproteins.
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关键词
proteins,synthesis,peptide-aminothiazoline
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