Skin-limited Langerhans Cell Histiocytosis in an Adult Presenting As Isolated, Eroded, “kissing” Intergluteal Plaques

Langerhans cell histiocytosis (LCH) is characterized by clonal proliferation of histiocytes accumulating in a variety of organs, most often the skin, bone, lungs, and pituitary gland.1,2 Although LCH is most commonly observed in children, it can rarely affect adults.3 While LCH can be skin-limited, most patients with cutaneous disease have multisystem involvement, which is associated with poorer prognosis.2 We report a case of an adult man with a history of liver transplant presenting with an intergluteal rash that was diagnosed as cutaneous LCH.