Synchronized ventilation during resuscitation in pigs does not necessitate high inspiratory pressures to provide adequate oxygenation

The optimal ventilation method for patients suffering from cardiac arrest and receiving cardiopulmonary resuscitation (CPR) remains unclear, and the recent guidelines do not provide detailed information.[1-3] During CPR, changing thoracic pressures due to chest compressions and ventilation pressure infl uence venous return and cardiac output, respectively.[4-6] Novel mechanical ventilation modes that are synchronized to chest compressions may improve blood flow and oxygenation.[4] In this porcine trial, we investigated the feasibility of a specially designed chest compression synchronized ventilation (CCSV) mode with peak pressures limited to 40 mbar (1 mbar=0.1 kPa) and an experimental synchronized ventilation (SV) limited to 20 mbar, respectively, intended to achieve a more lung -protective ventilation pattern during resuscitation. We evaluated whether the different synchronized pressure levels ameliorate hemodynamics, gas exchange and pulmonary function and compared it to intermittent positive pressure ventilation (IPPV).