Clinical and Endoscopic Differences Between Patients with Barrett's Esophagus with and Without Dysplasia/Adenocarcinoma

Introduction: Barrett's esophagus (BE) is the main precursor of esophageal adenocarcinoma (EAC). This study aimed to identify the risk factors associated with BE progression to dysplasia or EAC in a Latin population.Methods: The study is a retrospective analysis of a single-center cohort of patients with BE, evaluated from 2002 to 2012.Results: We identified 420 patients with BE; 281 (66.9%) of them were men with a mean age of 57.2 +/- 15.3 years. Among all BE patients evaluated, 81 (19.3%) had progression to some degree of dysplasia/EAC. The mean follow-up was 5.6 years. Multivariate analysis showed that age (OR = 1.03), cigarette smoking (OR = 3.05), long-segment BE (OR = 4.81), and a visible lesion on BE (OR = 6.94) were associated with progression to dysplasia/EAC. Conclusion: In Latin patients with BE, age, cigarette smoking, long-segment BE, and the presence of lesions were associated with the presence of dysplasia/EAC.