Simultaneous Monitoring of Amoxicillin and Paracetamol in Synthetic Biological Fluids Using a 3D Printed Disposable Electrode with a Lab-Made Conductive Filament

In this work, we are pleased to present for the first time a 3D-printed electrochemical device using a lab-made conductive filament based on graphite (Gr) and polylactic acid (PLA) polymer matrix for the simultaneous detection of amoxicillin (AMX) and paracetamol (PAR). The sensor was properly characterized by scanning electron microscopy (SEM), electrochemical impedance spectroscopy (EIS), and cyclic voltammetry (CV). Compared to the commercial glassy carbon electrode (GCE), the superior performance of the 3D-Gr/PLA electrode was verified with a 3.8-fold more favored charge transfer. A differential pulse voltammetry (DPV) method was proposed providing a linear working range of 4 to 12 μmol L-1 for both analytes and a limit of detection (LOD) of 0.80 and 0.51 μmol L-1 for AMX and PAR, respectively. Additionally, repeatability studies (n = 5, RSD < 5.7