Recent Advances in Microalgal Production, Harvesting, Prediction, Optimization, and Control Strategies.

The market value of microalgae has grown exponentially over the past two decades, due to their use in the pharmaceutical, nutraceutical, cosmetic, and aquatic/animal feed industries. In particular, high-value products such as omega-3 fatty acids, proteins, and pigments derived from microalgae have high demand. However, the supply of these high-value microalgal bioproducts is hampered by several critical factors, including low biomass and bioproduct yields, inefficiencies in monitoring microalgal growth, and costly harvesting methods. To overcome these constraints, strategies such as synthetic biology, bubble generation, photobioreactor designs, electro-/magnetic-/bioflocculation, and artificial intelligence integration in microalgal production are being explored. These strategies have significant promise in improving the production of microalgae, which will further boost market availability of algal-derived bioproducts. This review focuses on the recent advances in these technologies. Furthermore, this review aims to provide a critical analysis of the challenges in existing algae bioprocessing methods, and highlights future research directions.