Recent research advances in metabolism, clinical and experimental.

Metabolic disorders such as obesity, type 2 diabetes mellitus (T2DM), dyslipidemia, and non-alcoholic fatty liver disease (NAFLD) – henceforth named metabolic dysfunction-associated steatotic liver disease (MASLD), currently affect a large portion of the general population [ 1 Chakhtoura M. Haber R. Ghezzawi M. Rhayem C. Tcheroyan R. Mantzoros C.S. Pharmacotherapy of obesity: an update on the available medications and drugs under investigation. EClinicalMedicine. 2023; 58101882https://doi.org/10.1016/j.eclinm.2023.101882 Abstract Full Text Full Text PDF Scopus (24) Google Scholar , 2 Boutari C. Mantzoros C.S. A 2022 update on the epidemiology of obesity and a call to action: as its twin COVID-19 pandemic appears to be receding, the obesity and dysmetabolism pandemic continues to rage on. Metabolism. 2022; 133https://doi.org/10.1016/J.METABOL.2022.155217 Abstract Full Text Full Text PDF PubMed Google Scholar , 3 Kokkorakis M. Katsarou A. Katsiki N. Mantzoros C.S. Milestones in the journey towards addressing obesity; past trials and triumphs, recent breakthroughs, and an exciting future in the era of emerging effective medical therapies and integration of effective medical therapies with metabolic surgery. Metabolism. 2023; 148155689https://doi.org/10.1016/J.METABOL.2023.155689 Abstract Full Text Full Text PDF PubMed Google Scholar ]. Due to the complications that they are associated with, namely cardiovascular diseases [CVD] and even mortality, metabolic disorders have an appreciable impact on productivity and quality of life, and they constitute a challenge to the healthcare systems [ [4] Rodrigues K.F. Yong W.T.L. Bhuiyan M.S.A. Siddiquee S. Shah M.D. Venmathi Maran B.A. Current understanding on the genetic basis of key metabolic disorders: a review. Biology (Basel). 2022; : 11https://doi.org/10.3390/BIOLOGY11091308 Crossref PubMed Google Scholar , [5] Chew N.W.S. Ng C.H. Tan D.J.H. Kong G. Lin C. Chin Y.H. et al. The global burden of metabolic disease: data from 2000 to 2019. Cell Metab. 2023; 35: 414-428.e3https://doi.org/10.1016/j.cmet.2023.02.003 Abstract Full Text Full Text PDF PubMed Scopus (40) Google Scholar ]. Ever since the last overview of research advances published in Metabolism, Clinical and Experimental [ [6] Boutari C. Bouzoni E. Joshi A. Stefanakis K. Farr O.M. Mantzoros C.S. Metabolism updates: new directions, techniques, and exciting research that is broadening the horizons. Metabolism. 2020; : 102https://doi.org/10.1016/J.METABOL.2019.154009 Abstract Full Text Full Text PDF Google Scholar ], and particularly during the 2021–2022 biennial, despite the COVID-19 pandemic that was a global health emergency, there had been a parallel increase in the attention to metabolic disorders, and remarkable progress was made in metabolic research, with the field being ever expanding and encompassing all aspects of cardiometabolic health. We have selected and present herein the most outstanding and most cited original articles and reviews published in Metabolism, Clinical and Experimental over this biennium concerning the pathophysiology of important metabolic disorders, their complications, their association with COVID-19 infection, and promising novel therapeutics.