Sensitive MRD detection from lymphatic fluid after surgery in HPV-associated oropharyngeal cancer.

Noah Earland,Nicholas P Semenkovich,Ricardo J Ramirez,Sophie P Gerndt,Peter K Harris, Zhuosheng Gu,Andrew I Hearn,Matthew Inkman,Jeffrey J Szymanski, Damion Whitfield,Benjamin M Wahle, Zhongping Xu,Kevin Chen, Irfan Alahi, Gabris Ni, Andrew Chen,Wendy Winckler,Jin Zhang,Aadel A Chaudhuri,Jose P Zevallos

Clinical cancer research : an official journal of the American Association for Cancer Research（2023）

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摘要

Variant and cf-HPV quantification, performed in 24-hour postoperative lymph samples, reflect single- and multi-feature high-risk pathological criteria. Incorporating lymphatic MRD and clinicopathological feature analysis can stratify PFS early after surgery in patients with HPV (+) head and neck cancer.

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关键词

sensitive mrd detection,lymphatic fluid,oropharyngeal cancer,hpv-associated

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